Handy Backup fully supports Wasabi storage. For additional details, refer to Wasabi Backup Software - Handy Backup. To use Wasabi S3 as the backup destination, you can create a connection to it in the new task wizard.
This configuration example discusses the use of Wasabi's us-east-1 storage region. To use other Wasabi storage regions, please use the appropriate Wasabi service URL as described in Service URLs for Wasabi's Storage Regions.
Requirements
Download and install the latest version of Handy Backup. For more information, refer to Download Handy Backup. (Note that it has a 30-day free trial period.)
Open Handy Backup.
Click the New task button on the control panel.

On Step 1 of the new task wizard, choose a backup task. Click Next.

Select your data to back up in Step 2. Proceed to the next step.
On Step 3, select the S3 Cloud plug-in and double-click on it. You will see the new window.

Double-click the Create a connection string.
In the connection dialog, enter the following parameters.
Server Name—s3.wasabisys.com (for us-east), s3.us-west-1.wasabisys.com (for us-west) or s3.eu-central-1.wasabisys.com (for eu-central)
Access key—Your Wasabi API access key
Secret key—Your Wasabi API secret key
Test your connection to ensure everything works smoothly. Click OK to continue.
Double-click the connection name string. Handy Backup will open your Wasabi cloud.
Click OK to continue.
Proceed with creating a task step by step as described in the User Manual for Handy Backup.
You can use any options for Wasabi S3 backup without restrictions.
Give your task a distinctive name.
To complete the task setup, click Finish.